Antifibrogenic Effects of the Antimicrobial Peptide Cathelicidin in Murine Colitis-Associated Fibrosis

BACKGROUND & AIMS: Cathelicidin (LL-37 in human and mCRAMP in mice) represents a family of endogenous antimicrobial peptides with anti-inflammatory effects. LL-37 also suppresses collagen synthesis, an important fibrotic response, in dermal fibroblasts. Here, we determined whether exogenous cath...

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Dettagli Bibliografici
Pubblicato in:Cell Mol Gastroenterol Hepatol
Autori principali: Yoo, Jun Hwan, Ho, Samantha, Tran, Deanna Hoang-Yen, Cheng, Michelle, Bakirtzi, Kyriaki, Kubota, Yuzu, Ichikawa, Ryan, Su, Bowei, Tran, Diana Hoang-Ngoc, Hing, Tressia C., Chang, Irene, Shih, David Q., Issacson, Richard E., Gallo, Richard L., Fiocchi, Claudio, Pothoulakis, Charalabos, Koon, Hon Wai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2014
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338438/
https://ncbi.nlm.nih.gov/pubmed/25729764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2014.08.001
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