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Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels

Glutamate is an indispensable neurotransmitter, triggering postsynaptic signals upon recognition by postsynaptic receptors. We questioned the phylogenetic position and the molecular details of when and where glutamate recognition arose in the glutamate-gated chloride channels. Experiments revealed t...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lynagh, Timothy, Beech, Robin N., Lalande, Maryline J., Keller, Kevin, Cromer, Brett A., Wolstenholme, Adrian J., Laube, Bodo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338433/
https://ncbi.nlm.nih.gov/pubmed/25708000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08558
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