CD14 and Complement Crosstalk and Largely Mediate the Transcriptional Response to Escherichia coli in Human Whole Blood as Revealed by DNA Microarray

Systemic inflammation like in sepsis is still lacking specific diagnostic markers and effective therapeutics. The first line of defense against intruding pathogens and endogenous damage signals is pattern recognition by e.g., complement and Toll-like receptors (TLR). Combined inhibition of a key com...

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Bibliographic Details
Published in:PLoS One
Main Authors: Lau, Corinna, Nygård, Ståle, Fure, Hilde, Olstad, Ole Kristoffer, Holden, Marit, Lappegård, Knut Tore, Brekke, Ole-Lars, Espevik, Terje, Hovig, Eivind, Mollnes, Tom Eirik
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338229/
https://ncbi.nlm.nih.gov/pubmed/25706641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117261
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