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Requirement of cAMP Signaling for Schwann Cell Differentiation Restricts the Onset of Myelination

Isolated Schwann cells (SCs) respond to cAMP elevation by adopting a differentiated post-mitotic state that exhibits high levels of Krox-20, a transcriptional enhancer of myelination, and mature SC markers such as the myelin lipid galactocerebroside (O1). To address how cAMP controls myelination, we...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Bacallao, Ketty, Monje, Paula V.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338006/
https://ncbi.nlm.nih.gov/pubmed/25705874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116948
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