Compartmentalized protective and detrimental effects of endogenous MIF mediated by CXCR2 in a mouse model of myocardial ischemia/reperfusion

OBJECTIVES: Here we aimed to clarify the role of CXCR2 in the macrophage migration inhibitory factor (MIF)-mediated effects after myocardial ischemia and reperfusion (I/R). As a pleiotropic chemokine-like cytokine, MIF has been identified to activate multiple receptors including CD74 and CXCR2. In m...

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Vydáno v:Arterioscler Thromb Vasc Biol
Hlavní autoři: Liehn, Elisa A., Kanzler, Isabella, Konschalla, Simone, Kroh, Andreas, Simsekyilmaz, Sakine, Sönmez, Tolga Taha, Bucala, Richard, Bernhagen, Jürgen, Weber, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337944/
https://ncbi.nlm.nih.gov/pubmed/23868943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.113.301633
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