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A Probabilistic Approach to Cooperativity of Ligand Binding by a Polyvalent Molecule

Cooperativity of ligand binding is defined operationally in terms of the Hill parameter n, whose values uniquely define the shape of the binding curve. When n is everywhere equal to 1 the system behaves as if the sites were all the same and independent. If at any point n is unequal to 1 the system i...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Wyman, Jeffries, Phillipson, Paul E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1974
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC433787/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4530314/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.9.3431
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