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Novel 3-nitrotriazole-based amides and carbinols as bifunctional anti-Chagasic agents
3-Nitro-1H-1,2,4-triazole-based amides with a linear, rigid core and 3-nitrotriazole-based fluconazole analogs were synthesized as dual functioning antitrypanosomal agents. Such compounds are excellent substrates for type I nitroreductase (NTR) located in the mitochondrion of trypanosomatids and, at...
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| Publicat a: | J Med Chem |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4337820/ https://ncbi.nlm.nih.gov/pubmed/25580906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5015742 |
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