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Novel 3-nitrotriazole-based amides and carbinols as bifunctional anti-Chagasic agents
3-Nitro-1H-1,2,4-triazole-based amides with a linear, rigid core and 3-nitrotriazole-based fluconazole analogs were synthesized as dual functioning antitrypanosomal agents. Such compounds are excellent substrates for type I nitroreductase (NTR) located in the mitochondrion of trypanosomatids and, at...
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| Publicado no: | J Med Chem |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4337820/ https://ncbi.nlm.nih.gov/pubmed/25580906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5015742 |
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