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Defective apical extrusion signaling contributes to aggressive tumor hallmarks
When epithelia become too crowded, some cells are extruded that later die. To extrude, a cell produces the lipid, Sphingosine 1-Phosphate (S1P), which activates S1P(2) receptors in neighboring cells that seamlessly squeeze the cell out of the epithelium. Here, we find that extrusion defects can cont...
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| Publicado no: | eLife |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4337653/ https://ncbi.nlm.nih.gov/pubmed/25621765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04069 |
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