Quantitative Shearing Linear Amplification Polymerase Chain Reaction: An Improved Method for Quantifying Lentiviral Vector Insertion Sites in Transplanted Hematopoietic Cell Systems

In gene therapy trials targeting blood disorders, it is important to detect dominance of transduced hematopoietic stem cell (HSC) clones arising from vector insertion site (VIS) effects. Current methods for VIS analysis often do not have defined levels of quantitative accuracy and therefore can fail...

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Publicat a:Hum Gene Ther Methods
Autors principals: Zhou, Sheng, Bonner, Melissa A., Wang, Yong-Dong, Rapp, Samuel, De Ravin, Suk See, Malech, Harry L., Sorrentino, Brian P.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2015
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337463/
https://ncbi.nlm.nih.gov/pubmed/25545666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2014.122
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