Quantitative Shearing Linear Amplification Polymerase Chain Reaction: An Improved Method for Quantifying Lentiviral Vector Insertion Sites in Transplanted Hematopoietic Cell Systems

In gene therapy trials targeting blood disorders, it is important to detect dominance of transduced hematopoietic stem cell (HSC) clones arising from vector insertion site (VIS) effects. Current methods for VIS analysis often do not have defined levels of quantitative accuracy and therefore can fail...

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Veröffentlicht in:Hum Gene Ther Methods
Hauptverfasser: Zhou, Sheng, Bonner, Melissa A., Wang, Yong-Dong, Rapp, Samuel, De Ravin, Suk See, Malech, Harry L., Sorrentino, Brian P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2015
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337463/
https://ncbi.nlm.nih.gov/pubmed/25545666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2014.122
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