Quantitative Shearing Linear Amplification Polymerase Chain Reaction: An Improved Method for Quantifying Lentiviral Vector Insertion Sites in Transplanted Hematopoietic Cell Systems

In gene therapy trials targeting blood disorders, it is important to detect dominance of transduced hematopoietic stem cell (HSC) clones arising from vector insertion site (VIS) effects. Current methods for VIS analysis often do not have defined levels of quantitative accuracy and therefore can fail...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther Methods
Main Authors: Zhou, Sheng, Bonner, Melissa A., Wang, Yong-Dong, Rapp, Samuel, De Ravin, Suk See, Malech, Harry L., Sorrentino, Brian P.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337463/
https://ncbi.nlm.nih.gov/pubmed/25545666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2014.122
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