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Shikonin Induces Apoptosis, Necrosis, and Premature Senescence of Human A549 Lung Cancer Cells through Upregulation of p53 Expression

Shikonin, a natural naphthoquinone pigment isolated from Lithospermum erythrorhizon, has been reported to suppress growth of various cancer cells. This study was aimed to investigate whether this chemical could also inhibit cell growth of lung cancer cells and, if so, works via what molecular mechan...

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Publicat a:Evid Based Complement Alternat Med
Autors principals: Yeh, Yueh-Chiao, Liu, Tsun-Jui, Lai, Hui-Chin
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337265/
https://ncbi.nlm.nih.gov/pubmed/25737737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/620383
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