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Identification of Chloramphenicol-Binding Protein in Escherichia coli Ribosomes by Affinity Labeling

Monoiodoamphenicol, a synthetic analogue of chloramphenicol, has been shown by competition experiments with chloramphenicol and lincomycin to bind at the same site of 70S ribosomes as chloramphenicol. At — 2° it forms a 1:1 complex with 70S ribosomes having a value of K (7.5 × 10(4) M(-1)) that is o...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Pongs, Olaf, Bald, Rolf, Erdmann, Volker A.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 1973
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Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC433707/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4599619/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.70.8.2229
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