Prevention of Glucocorticoid Induced-Apoptosis of Osteoblasts and Osteocytes by Protecting against Endoplasmic Reticulum (ER) Stress in vitro and in vivo in Female Mice

Endoplasmic reticulum (ER) stress is associated with increased reactive oxygen species (ROS), results from accumulation of misfolded/unfolded proteins, and can trigger apoptosis. ER stress is alleviated by phosphorylation of eukaryotic translation initiation factor 2α (eIF2α), which inhibits protein...

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Publicado en:Bone
Autores principales: Sato, Amy Y., Tu, Xiaolin, McAndrews, Kevin A., Plotkin, Lilian I., Bellido, Teresita
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336847/
https://ncbi.nlm.nih.gov/pubmed/25532480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2014.12.012
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