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Acceleration of the Rate of Deamidation of GlyArgAsnArgGly and of Human Transferrin by Addition of l-Ascorbic Acid

Experiments on the model peptide, GlyArgAsnArgGly, and the protein, human transferrin, have shown that hydrolytic deamidation of these molecules is markedly accelerated by addition of physiologically significant concentrations of l-ascorbic acid. Since hydrolytic demidation has been suggested as an...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Robinson, Arthur B., Irving, Karen, McCrea, Mary
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1973
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC433679/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4516209/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.70.7.2122
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