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A distant, cis-acting enhancer drives induction of Arf by Tgfβ in the developing eye
The Arf tumor suppressor represents one of several genes encoded at the Cdkn2a and Cdkn2b loci in the mouse. Beyond its role blunting the growth of incipient cancer cells, the Arf gene also plays an essential role in development: Its gene product, p19(Arf), is induced by Tgfβ2 in the developing eye...
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| Publicado no: | Dev Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4336776/ https://ncbi.nlm.nih.gov/pubmed/23665474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2013.05.003 |
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