Tgfβ Signaling Directly Induces Arf Promoter Remodeling by a Mechanism Involving Smads 2/3 and p38 MAPK

We have investigated how the Arf gene product, p19(Arf), is activated by Tgfβ during mouse embryo development to better understand how this important tumor suppressor is controlled. Taking advantage of new mouse models, we provide genetic evidence that Arf lies downstream of Tgfβ signaling in cells...

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Bibliografske podrobnosti
Main Authors: Zheng, Yanbin, Zhao, Yi D., Gibbons, Melissa, Abramova, Tatiana, Chu, Patricia Y., Ash, John D., Cunningham, John M., Skapek, Stephen X.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Developmental Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975190/
https://ncbi.nlm.nih.gov/pubmed/20826783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.128959
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