Randomized, Placebo-controlled Trial of Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis: The ACROSS Trial

OBJECTIVE: This trial evaluated the efficacy of acetaminophen in reducing oxidative injury, as measured by plasma F(2)-Isoprostanes, in adult patients with severe sepsis and detectable plasma cell-free hemoglobin. DESIGN: Single center, randomized, double-blind, placebo controlled phase II trial. SE...

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Bibliografische gegevens
Gepubliceerd in:Crit Care Med
Hoofdauteurs: Janz, David R, Bastarache, Julie A, Rice, Todd W, Bernard, Gordon R, Warren, Melissa A, Wickersham, Nancy, Sills, Gillian, Oates, John A, Roberts, L Jackson, Ware, Lorraine B
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336619/
https://ncbi.nlm.nih.gov/pubmed/25474535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000000718
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