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Activation of NOTCH1 or NOTCH3 Signaling Skews Human Airway Basal Cell Differentiation toward a Secretory Pathway

Airway basal cells (BC) function as stem/progenitor cells capable of differentiating into the luminal ciliated and secretory cells to replenish the airway epithelium during physiological turnover and repair. The objective of this study was to define the role of Notch signaling in regulating human ai...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gomi, Kazunori, Arbelaez, Vanessa, Crystal, Ronald G., Walters, Matthew S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336283/
https://ncbi.nlm.nih.gov/pubmed/25700162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116507
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