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Tmem100 is a regulator of TRPA1-TRPV1 complex and contributes to persistent pain
TRPA1 and TRPV1 are crucial pain mediators, but how their interaction contributes to persistent pain is unknown. Here, we identify Tmem100 as a potentiating modulator of TRPA1-V1 complexes. Tmem100 is co-expressed and forms a complex with TRPA1 and TRPV1 in DRG neurons. Tmem100-deficient mice show a...
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| Pubblicato in: | Neuron |
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| Autori principali: | , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4336228/ https://ncbi.nlm.nih.gov/pubmed/25640077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.12.065 |
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