Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization

The pharmacological desensitization of receptors is a fundamental mechanism for regulating the activity of neuronal systems. The TRPA1 channel plays a key role in the processing of noxious information and can undergo functional desensitization by unknown mechanisms. Here we show that TRPA1 is desens...

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Hlavní autoři: Akopian, Armen N, Ruparel, Nikita B, Jeske, Nathaniel A, Hargreaves, Kenneth M
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2007
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2277224/
https://ncbi.nlm.nih.gov/pubmed/17584831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.133231
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