Tmem100 is a regulator of TRPA1-TRPV1 complex and contributes to persistent pain

TRPA1 and TRPV1 are crucial pain mediators, but how their interaction contributes to persistent pain is unknown. Here, we identify Tmem100 as a potentiating modulator of TRPA1-V1 complexes. Tmem100 is co-expressed and forms a complex with TRPA1 and TRPV1 in DRG neurons. Tmem100-deficient mice show a...

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Publicat a:Neuron
Autors principals: Weng, Hao-Jui, Patel, Kush N., Jeske, Nathaniel A., Bierbower, Sonya M., Zou, Wangyuan, Tiwari, Vinod, Zheng, Qin, Tang, Zongxiang, Mo, Gary C.H., Wang, Yan, Geng, Yixun, Zhang, Jin, Guan, Yun, Akopian, Armen, Dong, Xinzhong
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336228/
https://ncbi.nlm.nih.gov/pubmed/25640077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.12.065
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