Alkylphosphocholine Analogs for Broad-Spectrum Cancer Imaging and Therapy

Many solid tumors contain an overabundance of phospholipid ethers relative to normal cells. Capitalizing on this difference, we created cancer-targeted alkylphosphocholine (APC) analogs through structure-activity analyses. Depending on the iodine isotope used, radioiodinated APC analog CLR1404 was u...

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Publicado en:Sci Transl Med
Autores principales: Weichert, Jamey P., Clark, Paul A., Kandela, Irawati K., Vaccaro, Abram M., Clarke, William, Longino, Marc A., Pinchuk, Anatoly N., Farhoud, Mohammed, Swanson, Kyle I., Floberg, John M., Grudzinski, Joseph, Titz, Benjamin, Traynor, Anne M., Chen, Hong-En, Hall, Lance T., Pazoles, Christopher J., Pickhardt, Perry J., Kuo, John S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336181/
https://ncbi.nlm.nih.gov/pubmed/24920661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3007646
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