Novel Dengue Virus NS2B/NS3 Protease Inhibitors

Dengue fever is a severe, widespread, and neglected disease with more than 2 million diagnosed infections per year. The dengue virus NS2B/NS3 protease (PR) represents a prime target for rational drug design. At the moment, there are no clinical PR inhibitors (PIs) available. We have identified diary...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Wu, Hongmei, Bock, Stefanie, Snitko, Mariya, Berger, Thilo, Weidner, Thomas, Holloway, Steven, Kanitz, Manuel, Diederich, Wibke E., Steuber, Holger, Walter, Christof, Hofmann, Daniela, Weißbrich, Benedikt, Spannaus, Ralf, Acosta, Eliana G., Bartenschlager, Ralf, Engels, Bernd, Schirmeister, Tanja, Bodem, Jochen
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335830/
https://ncbi.nlm.nih.gov/pubmed/25487800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03543-14
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