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A Combined Genetic-Proteomic Approach Identifies Residues within Dengue Virus NS4B Critical for Interaction with NS3 and Viral Replication

Dengue virus (DENV) infection causes the most prevalent arthropod-borne viral disease worldwide. Approved vaccines are not available, and targets suitable for the development of antiviral drugs are lacking. One possible drug target is nonstructural protein 4B (NS4B), because it is absolutely require...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Chatel-Chaix, Laurent, Fischl, Wolfgang, Scaturro, Pietro, Cortese, Mirko, Kallis, Stephanie, Bartenschlager, Marie, Fischer, Bernd, Bartenschlager, Ralf
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4473547/
https://ncbi.nlm.nih.gov/pubmed/25926641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00867-15
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