A Combined Genetic-Proteomic Approach Identifies Residues within Dengue Virus NS4B Critical for Interaction with NS3 and Viral Replication

Dengue virus (DENV) infection causes the most prevalent arthropod-borne viral disease worldwide. Approved vaccines are not available, and targets suitable for the development of antiviral drugs are lacking. One possible drug target is nonstructural protein 4B (NS4B), because it is absolutely require...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Chatel-Chaix, Laurent, Fischl, Wolfgang, Scaturro, Pietro, Cortese, Mirko, Kallis, Stephanie, Bartenschlager, Marie, Fischer, Bernd, Bartenschlager, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4473547/
https://ncbi.nlm.nih.gov/pubmed/25926641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00867-15
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