In Vitro and In Vivo Antiviral Activity and Resistance Profile of Ombitasvir, an Inhibitor of Hepatitis C Virus NS5A

Ombitasvir (ABT-267) is a hepatitis C virus (HCV) NS5A inhibitor with picomolar potency, pan-genotypic activity, and 50% effective concentrations (EC(50)s) of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a. Ombitasvir retained these levels of potency against a panel of 6...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Krishnan, Preethi, Beyer, Jill, Mistry, Neeta, Koev, Gennadiy, Reisch, Thomas, DeGoey, David, Kati, Warren, Campbell, Andrew, Williams, Laura, Xie, Wangang, Setze, Carolyn, Molla, Akhteruzzaman, Collins, Christine, Pilot-Matias, Tami
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335823/
https://ncbi.nlm.nih.gov/pubmed/25451055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04226-14
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