In Vitro Activity and Resistance Profile of Dasabuvir, a Nonnucleoside Hepatitis C Virus Polymerase Inhibitor

Dasabuvir (ABT-333) is a nonnucleoside inhibitor of the RNA-dependent RNA polymerase encoded by the hepatitis C virus (HCV) NS5B gene. Dasabuvir inhibited recombinant NS5B polymerases derived from HCV genotype 1a and 1b clinical isolates, with 50% inhibitory concentration (IC(50)) values between 2.2...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Kati, Warren, Koev, Gennadiy, Irvin, Michelle, Beyer, Jill, Liu, Yaya, Krishnan, Preethi, Reisch, Thomas, Mondal, Rubina, Wagner, Rolf, Molla, Akhteruzzaman, Maring, Clarence, Collins, Christine
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325770/
https://ncbi.nlm.nih.gov/pubmed/25534735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04619-14
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