Spatio-temporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cul3-RhoA pathway in psychiatric diseases

Psychiatric disorders autism and schizophrenia have a strong genetic component, and copy number variants (CNVs) are firmly implicated. Recurrent deletions and duplications of chromosome 16p11.2 confer high risk for both diseases, but the pathways disrupted by this CNV are poorly defined. Here we inv...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Lin, Guan Ning, Corominas, Roser, Lemmens, Irma, Yang, Xinping, Tavernier, Jan, Hill, David E., Vidal, Marc, Sebat, Jonathan, Iakoucheva, Lilia M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335356/
https://ncbi.nlm.nih.gov/pubmed/25695269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.01.010
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