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Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy

Owing to their integral involvement in cell cycle regulation, the Polo-like kinase (Plk) family, particularly Plk1, has emerged as an attractive therapeutic target in oncology. In recent years, several Plk1 inhibitors have been developed, with some agents showing encouraging results in early-phase c...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Gjertsen, B T, Schöffski, P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335352/
https://ncbi.nlm.nih.gov/pubmed/25027517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.222
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