Učitavanje...
The E–Id protein axis modulates the activities of the PI3K–AKT–mTORC1–Hif1a and c-myc/p19Arf pathways to suppress innate variant T(FH) cell development, thymocyte expansion, and lymphomagenesis
It is now well established that the E and Id protein axis regulates multiple steps in lymphocyte development. However, it remains unknown how E and Id proteins mechanistically enforce and maintain the naïve T-cell fate. Here we show that Id2 and Id3 suppressed the development and expansion of innate...
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| Izdano u: | Genes Dev |
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| Glavni autori: | , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4335296/ https://ncbi.nlm.nih.gov/pubmed/25691468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.255331.114 |
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