The E–Id protein axis modulates the activities of the PI3K–AKT–mTORC1–Hif1a and c-myc/p19Arf pathways to suppress innate variant T(FH) cell development, thymocyte expansion, and lymphomagenesis

It is now well established that the E and Id protein axis regulates multiple steps in lymphocyte development. However, it remains unknown how E and Id proteins mechanistically enforce and maintain the naïve T-cell fate. Here we show that Id2 and Id3 suppressed the development and expansion of innate...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Miyazaki, Masaki, Miyazaki, Kazuko, Chen, Shuwen, Chandra, Vivek, Wagatsuma, Keisuke, Agata, Yasutoshi, Rodewald, Hans-Reimer, Saito, Rintaro, Chang, Aaron N., Varki, Nissi, Kawamoto, Hiroshi, Murre, Cornelis
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335296/
https://ncbi.nlm.nih.gov/pubmed/25691468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.255331.114
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