Structural Basis for the Formation of Acylalkylpyrones from Two β-Ketoacyl Units by the Fungal Type III Polyketide Synthase CsyB

The acylalkylpyrone synthase CsyB from Aspergillus oryzae catalyzes the one-pot formation of the 3-acyl-4-hydroxy-6-alkyl-α-pyrone scaffold from acetoacetyl-CoA, fatty acyl-CoA, and malonyl-CoA. This is the first type III polyketide synthase that performs not only the polyketide chain elongation but...

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Vydáno v:J Biol Chem
Hlavní autoři: Mori, Takahiro, Yang, Dengfeng, Matsui, Takashi, Hashimoto, Makoto, Morita, Hiroyuki, Fujii, Isao, Abe, Ikuro
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335254/
https://ncbi.nlm.nih.gov/pubmed/25564614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.626416
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