Phosphorylation of TET Proteins Is Regulated via O-GlcNAcylation by the O-Linked N-Acetylglucosamine Transferase (OGT)

TET proteins oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine and thus provide a possible means for active DNA demethylation in mammals. Although their catalytic mechanism is well characterized and the catalytic dioxygenase domain is highly conserved, the...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Bauer, Christina, Göbel, Klaus, Nagaraj, Nagarjuna, Colantuoni, Christian, Wang, Mengxi, Müller, Udo, Kremmer, Elisabeth, Rottach, Andrea, Leonhardt, Heinrich
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
DNA and Chromosomes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335217/
https://ncbi.nlm.nih.gov/pubmed/25568311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.605881
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