Direct Interaction of Ca(V)β with Actin Up-regulates L-type Calcium Currents in HL-1 Cardiomyocytes

Expression of the β-subunit (Ca(V)β) is required for normal function of cardiac L-type calcium channels, and its up-regulation is associated with heart failure. Ca(V)β binds to the α(1) pore-forming subunit of L-type channels and augments calcium current density by facilitating channel opening and i...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Stölting, Gabriel, de Oliveira, Regina Campos, Guzman, Raul E., Miranda-Laferte, Erick, Conrad, Rachel, Jordan, Nadine, Schmidt, Silke, Hendriks, Johnny, Gensch, Thomas, Hidalgo, Patricia
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Membrane Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335199/
https://ncbi.nlm.nih.gov/pubmed/25533460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.573956
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