Rapid Turnover of the Cardiac L-Type Ca(V)1.2 Channel by Endocytic Recycling Regulates Its Cell Surface Availability

Calcium entry through Ca(V)1.2 L-type calcium channels regulates cardiac contractility. Here, we study the impact of exocytic and post-endocytic trafficking on cell surface channel abundance in cardiomyocytes. Single-molecule localization and confocal microscopy reveal an intracellular Ca(V)1.2 pool...

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Udgivet i:iScience
Main Authors: Conrad, Rachel, Stölting, Gabriel, Hendriks, Johnny, Ruello, Giovanna, Kortzak, Daniel, Jordan, Nadine, Gensch, Thomas, Hidalgo, Patricia
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135870/
https://ncbi.nlm.nih.gov/pubmed/30267672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.08.012
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