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Interaction between the tRNA-Binding and C-Terminal Domains of Yeast Gcn2 Regulates Kinase Activity In Vivo

The stress-activated protein kinase Gcn2 regulates protein synthesis by phosphorylation of translation initiation factor eIF2α. Gcn2 is activated in amino acid-deprived cells by binding of uncharged tRNA to the regulatory domain related to histidyl-tRNA synthetase, but the molecular mechanism of act...

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Publicat a:PLoS Genet
Autors principals: Lageix, Sebastien, Zhang, Jinwei, Rothenburg, Stefan, Hinnebusch, Alan G.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335047/
https://ncbi.nlm.nih.gov/pubmed/25695491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004991
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