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An Integrative Multi-scale Analysis of the Dynamic DNA Methylation Landscape in Aging

Recent studies have demonstrated that the DNA methylome changes with age. This epigenetic drift may have deep implications for cellular differentiation and disease development. However, it remains unclear how much of this drift is functional or caused by underlying changes in cell subtype compositio...

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Vydáno v:PLoS Genet
Hlavní autoři: Yuan, Tian, Jiao, Yinming, de Jong, Simone, Ophoff, Roel A., Beck, Stephan, Teschendorff, Andrew E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334892/
https://ncbi.nlm.nih.gov/pubmed/25692570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004996
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