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Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP
Striatal-enriched protein tyrosine phosphatase (STEP) is a brain specific protein tyrosine phosphatase that has been implicated in many neurodegenerative diseases, such as Alzheimer’s disease. We recently reported the benzopentathiepin TC-2153 as a potent inhibitor of STEP in vitro, cells and animal...
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| Publicado en: | Bioorg Med Chem Lett |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4334692/ https://ncbi.nlm.nih.gov/pubmed/25666825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.01.020 |
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