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Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP

Striatal-enriched protein tyrosine phosphatase (STEP) is a brain specific protein tyrosine phosphatase that has been implicated in many neurodegenerative diseases, such as Alzheimer’s disease. We recently reported the benzopentathiepin TC-2153 as a potent inhibitor of STEP in vitro, cells and animal...

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Publicat a:Bioorg Med Chem Lett
Autors principals: Baguley, Tyler D., Nairn, Angus C., Lombroso, Paul J., Ellman, Jonathan A.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334692/
https://ncbi.nlm.nih.gov/pubmed/25666825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.01.020
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