Direct Measurement of the pK Values of an Alkaline Bohr Group in Human Hemoglobin

Proton nuclear magnetic resonance spectra of normal and des-(his 146β) human hemoglobin in the aromatic resonance region have been compared at different pH values. From these measurements, a pK value for histidine 146β of 7.1 in carbonmonoxyhemoglobin and 8.0 in deoxyhemoglobin has been found. These...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Kilmartin, J. V., Breen, J. J., Roberts, G. C. K., Ho, C.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1973
Soggetti:	Biological Sciences: Biochemistry
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC433468/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4515623/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.70.4.1246
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