Muscle IGF-1-Induced Skeletal Muscle Hypertrophy Evokes Higher Insulin Sensitivity and Carbohydrate Use as Preferential Energy Substrate

We characterized the metabolic profile of transgenic mice exhibiting enhanced muscle mass driven by increased mIGF-1 expression (MLC/mIGF-1). As expected, 6-month-old MLC/mIGF-1 mice were heavier than age-matched wild type (WT) mice (37.4 ± 0.3 versus 31.8 ± 0.6 g, resp.). MLC/mIGF-1 mice had higher...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Christoffolete, Marcelo Augusto, Silva, William Jose, Ramos, Gracielle Vieira, Bento, Mirella Ribeiro, Costa, Monique Oliveira, Ribeiro, Miriam Oliveira, Okamoto, Maristela Mitiko, Lohmann, Tania Helena, Machado, Ubiratan Fabres, Musarò, Antonio, Moriscot, Anselmo Sigari
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334619/
https://ncbi.nlm.nih.gov/pubmed/25722973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/282984
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