Muscle IGF-1-Induced Skeletal Muscle Hypertrophy Evokes Higher Insulin Sensitivity and Carbohydrate Use as Preferential Energy Substrate

We characterized the metabolic profile of transgenic mice exhibiting enhanced muscle mass driven by increased mIGF-1 expression (MLC/mIGF-1). As expected, 6-month-old MLC/mIGF-1 mice were heavier than age-matched wild type (WT) mice (37.4 ± 0.3 versus 31.8 ± 0.6 g, resp.). MLC/mIGF-1 mice had higher...

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Vydáno v:Biomed Res Int
Hlavní autoři: Christoffolete, Marcelo Augusto, Silva, William Jose, Ramos, Gracielle Vieira, Bento, Mirella Ribeiro, Costa, Monique Oliveira, Ribeiro, Miriam Oliveira, Okamoto, Maristela Mitiko, Lohmann, Tania Helena, Machado, Ubiratan Fabres, Musarò, Antonio, Moriscot, Anselmo Sigari
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334619/
https://ncbi.nlm.nih.gov/pubmed/25722973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/282984
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