Targeting of Non-Dominant Antigens as a Vaccine Strategy to Broaden T-Cell Responses during Chronic Viral Infection

In this study, we compared adenoviral vaccine vectors with the capacity to induce equally potent immune responses against non-dominant and immunodominant epitopes of murine lymphocytic choriomeningitis virus (LCMV). Our results demonstrate that vaccination targeting non-dominant epitopes facilitates...

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Bibliographic Details
Published in:PLoS One
Main Authors: Holst, Peter J., Jensen, Benjamin A. H., Ragonnaud, Emeline, Thomsen, Allan R., Christensen, Jan P.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334508/
https://ncbi.nlm.nih.gov/pubmed/25679375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117242
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