ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation

T follicular helper (Tfh) cells are essential in the induction of high-affinity, class-switched antibodies. The differentiation of Tfh cells is a multi-step process that depends upon the co-receptor ICOS and the activation of phosphoinositide-3 kinase leading to the expression of key Tfh cell genes....

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Publicat a:Immunity
Autors principals: Stone, Erica L., Pepper, Marion, Katayama, Carol D., Kerdiles, Yann M., Lai, Chen-Yen, Emslie, Elizabeth, Lin, Yin C., Yang, Edward, Goldrath, Ananda W., Li, Ming O., Cantrell, Doreen A., Hedrick, Stephen M.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334393/
https://ncbi.nlm.nih.gov/pubmed/25692700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.01.017
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