The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity

T follicular helper (Tfh) cells are crucial for regulating autoimmune inflammation and protective immunity against viral infection. However, the molecular mechanism controlling Tfh cell differentiation is poorly understood. Here, through two mixed bone marrow chimeric experiments, we identified Peli...

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Vydáno v:Cell Mol Immunol
Hlavní autoři: Huang, Xinfang, Hao, Shumeng, Liu, Junli, Huang, Yuanyuan, Liu, Manman, Xiao, Chunyuan, Wang, Yan, Pei, Siyu, Yu, Tao, Xu, Jing, Wang, Haikun, Dai, Dongfang, Su, Xiao, Xiao, Yichuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115645/
https://ncbi.nlm.nih.gov/pubmed/33707688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-021-00660-5
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