Role of the Nuclease of Nontypeable Haemophilus influenzae in Dispersal of Organisms from Biofilms

Nontypeable Haemophilus influenzae (NTHI) forms biofilms in the middle ear during human infection. The biofilm matrix of NTHI contains extracellular DNA. We show that NTHI possesses a potent nuclease, which is a homolog of the thermonuclease of Staphylococcus aureus. Using a biofilm dispersal assay,...

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Detalles Bibliográficos
Publicado en:Infect Immun
Main Authors: Cho, Christine, Chande, Aroon, Gakhar, Lokesh, Bakaletz, Lauren O., Jurcisek, Joseph A., Ketterer, Margaret, Shao, Jian, Gotoh, Kenji, Foster, Eric, Hunt, Jason, O'Brien, Erin, Apicella, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2015
Assuntos:
Molecular Pathogenesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333478/
https://ncbi.nlm.nih.gov/pubmed/25547799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02601-14
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