Role of the Nuclease of Nontypeable Haemophilus influenzae in Dispersal of Organisms from Biofilms

Nontypeable Haemophilus influenzae (NTHI) forms biofilms in the middle ear during human infection. The biofilm matrix of NTHI contains extracellular DNA. We show that NTHI possesses a potent nuclease, which is a homolog of the thermonuclease of Staphylococcus aureus. Using a biofilm dispersal assay,...

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Vydáno v:Infect Immun
Hlavní autoři: Cho, Christine, Chande, Aroon, Gakhar, Lokesh, Bakaletz, Lauren O., Jurcisek, Joseph A., Ketterer, Margaret, Shao, Jian, Gotoh, Kenji, Foster, Eric, Hunt, Jason, O'Brien, Erin, Apicella, Michael A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Molecular Pathogenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333478/
https://ncbi.nlm.nih.gov/pubmed/25547799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02601-14
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