Role of the Nuclease of Nontypeable Haemophilus influenzae in Dispersal of Organisms from Biofilms

Nontypeable Haemophilus influenzae (NTHI) forms biofilms in the middle ear during human infection. The biofilm matrix of NTHI contains extracellular DNA. We show that NTHI possesses a potent nuclease, which is a homolog of the thermonuclease of Staphylococcus aureus. Using a biofilm dispersal assay,...

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Bibliografiske detaljer
Udgivet i:Infect Immun
Main Authors: Cho, Christine, Chande, Aroon, Gakhar, Lokesh, Bakaletz, Lauren O., Jurcisek, Joseph A., Ketterer, Margaret, Shao, Jian, Gotoh, Kenji, Foster, Eric, Hunt, Jason, O'Brien, Erin, Apicella, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Molecular Pathogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333478/
https://ncbi.nlm.nih.gov/pubmed/25547799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02601-14
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