Role of the Nuclease of Nontypeable Haemophilus influenzae in Dispersal of Organisms from Biofilms

Nontypeable Haemophilus influenzae (NTHI) forms biofilms in the middle ear during human infection. The biofilm matrix of NTHI contains extracellular DNA. We show that NTHI possesses a potent nuclease, which is a homolog of the thermonuclease of Staphylococcus aureus. Using a biofilm dispersal assay,...

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Bibliographische Detailangaben
Veröffentlicht in:Infect Immun
Hauptverfasser: Cho, Christine, Chande, Aroon, Gakhar, Lokesh, Bakaletz, Lauren O., Jurcisek, Joseph A., Ketterer, Margaret, Shao, Jian, Gotoh, Kenji, Foster, Eric, Hunt, Jason, O'Brien, Erin, Apicella, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Molecular Pathogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333478/
https://ncbi.nlm.nih.gov/pubmed/25547799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02601-14
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