DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes

We explore the role of DNA damage processing in the progression of cognitive decline by creating a new mouse model. The new model is a cross of a common Alzheimer's disease (AD) mouse (3xTgAD), with a mouse that is heterozygous for the critical DNA base excision repair enzyme, DNA polymerase β....

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Sykora, Peter, Misiak, Magdalena, Wang, Yue, Ghosh, Somnath, Leandro, Giovana S., Liu, Dong, Tian, Jane, Baptiste, Beverly A., Cong, Wei-Na, Brenerman, Boris M., Fang, Evandro, Becker, Kevin G., Hamilton, Royce J., Chigurupati, Soumya, Zhang, Yongqing, Egan, Josephine M., Croteau, Deborah L., Wilson, David M., Mattson, Mark P., Bohr, Vilhelm A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333403/
https://ncbi.nlm.nih.gov/pubmed/25552414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1356
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